A biguanide antihyperglycaemic and antidiabetic used for type-2 diabetes, alone or with sulfonurea. I stopped taking it and for the last two days sugar levels have stayed between 115 and 135. Metformin sensitises cells to insulin, decreases serum glucose and insulin, decreases insulin resistance, increases glucose utilisation, decreases triglycerides, and reduces weight; in some patients, it suppresses appetite. Adverse effects GI tract complaints—e.g., diarrhoea, nausea, vomiting, bloating—occur in 30%. metformin is a substance name and there's all kind of drug companies that manufacture it (all in different names and little formula differences). I'm a diabetic and have been on metformin for aprox. Contraindications Metabolic acidosis, liver disease; metformin has an equal and additive effect with troglitazone, which acts by increased peripheral glucose disposal. A biguanide oral HYPOGLYCAEMIC drug used in the treatment of MATURITY ONSET DIABETES. biguanide agent used to treat diabetes mellitus; in presence of insulin, it decreases hepatic gluconeogenesis and increases peripheral uptake of glucose (i.e. Diabetology A biguanide antihyperglycemic and antidiabetic used for type 2 DM, alone or with sulfonurea; metformin sensitizes cells to insulin, ↓ serum glucose and insulin, ↓ insulin resistance, ↑ glucose utilization, ↓ TGs, ↓ weight; in some Pts, it suppresses appetite. The drug may be dangerous to those with liver or kidney disease or a high alcohol intake. it decreases peripheral insulin resistance); it is used to treat type 2 diabetes in cases that retain some endogenous pancreatic function, obese diabetics, and those whose blood glucose levels are not adequately controlled by sulphonylureas alone; also used in conjunction with sulphonylureas or acarbose or injected insulin or a glitazone or repaglinide; also used to treat some type 1 diabetics where it is used as an adjunct to parenteral (administered) insulin; may be used to treat polycystic ovary disease (these patients typically show insulin resistance, even though not frankly diabetic)A. You should remain on the new dosage for another week or two, and keep track of your sugar level meanwhile, and if things don't improve then you should see your doctor again so that he/she will make a new evaluation. 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